Publications

Papers & preprints

The research behind the POLARIS tools. This list is generated from the PDFs in /public/papers/ — drop in a new PDF and add an entry to update it.

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  PreprintbioRxiv · 2026CpG Atlas

  CpG Atlas: A centralized multi-layer database and AI interface for DNA methylation research

  Jenel F. Armstrong, Shawn Wahi, Daniel Borrus, Raghav Sehgal, Syed Rizvi, Shiyang Zhang, Macsue Jacques, Nir Eynon, David van Dijk, Albert Higgins-Chen

  PDF DOI Preprint
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  PreprintbioRxiv · 2026TranslAGE

  TranslAGE: A Comprehensive Platform for Systematic Validation of Epigenetic Aging Biomarkers

  Daniel S. Borrus, Raghav Sehgal, Jenel F. Armstrong, John Gonzalez, Grace Zou, et al., Albert Higgins-Chen

  PDF DOI Preprint
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  PreprintbioRxiv · 2025TranslAGE

  Biological versus Technical Reliability of Epigenetic Clocks and Implications for Disease Prognosis and Intervention Response

  Raghav Sehgal, Daniel Borrus, John Gonzalez, Yaroslav Markov, ADNI, Albert Higgins-Chen

  PDF DOI Preprint
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  PreprintbioRxiv · 2024TranslAGE

  DNAm aging biomarkers are responsive: Insights from 51 longevity interventional studies in humans

  Raghav Sehgal, Daniel Borrus, Jessica Kasamato, Jenel F. Armstrong, John Gonzalez, Yaroslav Markov, Ahana Priyanka, Ryan Smith, Natàlia Carreras, Varun B. Dwaraka, Albert Higgins-Chen

  PDF DOI Preprint
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  PreprintbioRxiv · 2022methylCIPHER

  methylCIPHER: A Methylation Clock Investigational Package for Hypothesis-Driven Evaluation & Research

  Kyra L. Thrush, Albert T. Higgins-Chen, Zuyun Liu, Morgan E. Levine

  PDF DOI Preprint