Publications
Papers & preprints
Peer-reviewed papers and preprints from the Higgins-Chen Lab that underpin the POLARIS platform — the methods behind our aging-biomarker models and CpG-level annotation, the systematic benchmarking of epigenetic clocks, and the datasets and DNA-methylation biology they build on.
Responsiveness of epigenetic aging biomarkers to longevity interventions in humans
Raghav Sehgal, Daniel Borrus, Jenel F. Armstrong, John Gonzalez, Jessica Kasamoto, Yaroslav Markov, Ahana Priyanka, Ryan Smith, Natàlia Carreras-Gallo, Jessica Lasky-Su, Varun B. Dwaraka, Michael J. Corley, Albert Higgins-Chen
Before an epigenetic clock can serve as a surrogate endpoint in a trial, it has to actually move when an intervention works. We harmonized 51 longitudinal interventional studies into a single database and computed the same panel of biomarkers across all of them — showing which clocks respond, to which interventions, and under which study designs.
- Interventional studies
- 51Interventional studies
- Epigenetic clocks
- 16Epigenetic clocks
- Other DNAm biomarkers
- 94Other DNAm biomarkers
